Jacqueline Samantha Titone was born in 1974 in Coral Springs, Florida, to Lila Titone and Joseph Titone. She began modeling during high school and eventually became nationally, and internationally, known for modeling such clothing for big name companies. Jackie was later introduced into the acting world, by Rob Schneider in the 1999 hit movie Deuce Bigalow: Male Gigolo (1999), as “Sally”.
With the success of this movie, Rob Schneider put in a good word for Jackie to his good-friend, Adam Sandler, who offered a part to Jackie in the movie, Big Daddy (1999), in the year of 1999. She played the waitress and was also a music assistant. In the year of 2000, she played a part in the movie, Little Nicky (2000), alongside Adam Sandler, Reese Witherspoon, Patricia Arquette and Quentin Tarantino. A year later, Adam Sandler and Jackie came together in a relationship.
Two years later, Jackie was given a main part in the animated movie, Eight Crazy Nights (2002) as the voice of “Jennifer”, making this her first major role in a movie alongside a big star. In 2003, Danny DeVito offered a part to Jackie as the bartender in the movie, Duplex (2003).
On June 22, 2003, Adam and Jackie were married.
In 50 First Dates (2004), a 2004 hit comedy/romance movie, Adam Sandler and Drew Barrymore were offered parts in sharing the screen, together. Drew and Adam have co-starred in major movies previously but, this time, Adam demanded that his wife, Jackie, be given somewhat of a part in this movie, the director, Peter Segal, didn’t want to lose Adam as the main co-star, and gave the part of the dentist to Jackie. Because Adam only starred in this movie, he wasn’t able to offer a bigger part or a co-star part to his wife, Jackie.
In the year of 2004, Jackie starred as herself on the TV episode VH1: All Access: Celebrity Weddings, just one day before her one-year wedding anniversary with Adam.
Raised a Christian, she converted to Judaism when marrying Adam.